Aromatase inhibitors and the risk of cardiovascular outcomes in women with breast cancer. Aromasin is a brand-name prescription medication. I have MBC, diagnosed in Nov 2021. anastrozole (Arimidex), letrozole (Femara) and exemestane (Aromasin). I was dx with stage 2, multifocal DCIS, HER2+ and estrogen positive 6.5 cm mass, in February. Do what give you joy. I have, hard time controlling my bladder, and memory is definitely been affected along with mild hot flashes. How long does it take to to work through the withdrawal process? My scans are negative (yay) but I am Stage 4, so I am on chemo indefinitely. Yes, it was approved by my doc. In addition, Arimidex may affect your liver. Get answers to some frequently asked questions about Arimidexs side effects. I have been consistent. Stephanie L. Graff, MD, FACP summed up those results succinctly: Researchers presented results from several studies looking at genomic assays, tests that look at the genes of the tumor itself. #ASCO21. Christina, I don't blame you one bit for feeling cheated, mad and sad. Generally it takes four to five half-lives for a drug to be eliminated from the body, so in the case of Arimidex this would be 150 to 300 hours, or six to 12 days. In the IBIS-II trial, too few deaths were reported in the Arimidex Vs Placebo . Definitely having some type of withdrawal. If that's a donut, go for it. Hope you're doing well despite the nasty cancer side effects. 4. Now I walk 30 minutes a day to YouTube walking videos. Glad benefit is durable. It does this by inhibiting the enzyme aromatase, which converts these androgens into estrogen. I still take it off slowly. If Im surmising correctly, who benefits from these assays might be more nuanced. You may develop a skin rash while taking anastrozole. I did find. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. The last time I took my blood pressure, it was 117/70. Had 8." + (show) Anastrozole did indeed do a number of adverse things to my skin, hair, bones, and joints, etc., but from what I read, my memory issues were likely an effect of the chemotherapy (Taxol in my case) at my age. Arimidex may increase your cholesterol. Interested in more discussions like this? If youre pregnant or breastfeeding, or planning to become pregnant or breastfeed, talk with your doctor before starting Arimidex. Source: Tweet below from recent #ASCO21 Conference. Your specialist may suggest changing to a differentaromatase inhibitorsuch asletrozoleorexemestane, or anotherhormone treatment, as some women get on better with a different drug. If youve had an allergic reaction to Arimidex or any of its ingredients, you shouldnt take Arimidex. How soon do the side effects of Arimidex start? I have experienced sore muscles and joints as well but persist with walking and Pilates. If youre concerned about this you may find it helpful to speak to your specialist. Bone loss is serious. If youre experiencing any or all of these, its not fun. Receiving a new breast cancer diagnosis can feel scary, but you are not alone. I hope this is some encouragement. Brisk walking can also be beneficial. MY choice was to not take the AIs. 1998-2023 Mayo Foundation for Medical Education and Research. But this side effect was more commonly reported in those taking the medication for advanced breast cancer. Arimidex (anastrozole) is a medication that is used to treat breast cancer in postmenopausal women. Complete your request online or contact us by phone. You may have menopausal symptoms such as hot flushes, sweating, sleep disturbance, vaginal irritation such as dryness and itching, and reduced libido (sex drive). I love to eat! Since Nov. 1 I have been to the gym 5 days a week, missing only an occasional day here and there (maybe a total of 5). I hope for a speedy recovery for you! https://www.medicalnewstoday.com/articles/arimidex. Since it takes three weeks to get it out of your body not sure we are going to be able to tell much. If youre male and your doctor has recommended that you take Arimidex, talk with them about the drugs possible side effects. I would love to walk but have a bad knee. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. If you struggle to maintain a healthy weight, ask your GP or specialist about being referred to a dietician. Is it related to", "I too stopped taking Arimidex after five years now have enlarged fatty liver, osteopenia, debilitating fatigue,", "I have been on Anastrozole for almost 2 months, take it at night. There are CDs, podcasts and phone apps that can guide you through these techniques. It is important to me to be able to exercise every day and feel well. Dosage for Arimidex: What You Need to Know, accessdata.fda.gov/drugsatfda_docs/label/2018/020541s031lbl.pdf, ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.044750, 7 Things I Would Tell Someone Recently Diagnosed with Breast Cancer, Breast Cancer Treatment: Why Some Older Patients May Not Need Radiation, TV Host Samantha Harris Says her Breast Cancer Was Misdiagnosed for Months. This has happened to me too. You kick some too!!! React. I'm sorry you're dealing with so much and don't have the option of stopping your AI med unless, of course, you have to switch treatment regimens entirely. Donna, Cynthia, I replied to your response but not knowing exactly what to do I did it wrong so you can go back and read it. 5 Tips for Getting Back Into a Routine Post Holidays & a New Freebie! Let me repeat, I am not endorsing stopping early or not starting, for that matter. Where do the lines of osteoporosis danger and cancer recurrence intersect? Losing weight safely while breastfeeding is possible as long as you are nursing on demand and eating enough food . Anastrozole can occasionally cause changes to how the liver works. Watch on. This may or may not give you hope that things might improve for you too. I am going through a similar thing and am taking a three week break from Anastrozole as I had such severe knee and leg pain, wrists, hands, etc. At least they didnt for me. I'm sorry to hear about your diverticulitis! What are the more common side effects of Arimidex? Last medically reviewed on November 18, 2021. Being hypertensive and being overweightare known risk factors and they are both things I can try tocontrol. I am done with aromatase inhibitors! These symptoms usually improve or become easier to manage over time. Find out more aboutdiet and breast cancer treatment. Find out more about hair loss and thinning. It is a place to learn, discuss and share experiences and information. sparklegram | @sparklegram | Apr 11, 2019 To calculate your BMI, enter your height and weight . However, for some people they may cause distress and disrupt everyday life. Arimidex lowers estrogen levels by preventing the synthesis of estrogen from adrenal androgens (primarily androstenedione and testosterone). There's no way to completely predict or prevent breast cancer. Our website services, content, and products are for informational purposes only. These symptoms could be life threatening and require immediate medical care. Connect with thousands of patients and caregivers for support and answers. Symptoms to watch for include: Your doctor may monitor your liver function throughout Arimidex treatment to check for liver problems. This does not mean I am endorsing stopping early. If you decrease your daily calorie intake as a result, you could potentially lose weight by stopping your antidepressants. Almost everyone that I have chatted with has had terrible, SE with this. The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. Women were considered high risk if they had two or more blood relatives with breast cancer, a mother or sister who developed breast cancer before the age of 50, or a mother or sister who had breast cancer in both breasts. This is especially helpful to do when you first start taking new drugs or using a combination of treatments. Arimidex works by decreasing levels of estrogen, which is a female hormone. * The medication isnt approved for use in males* with breast cancer or other conditions. What happens when you stop taking Arimidex? Before you start taking Arimidex, talk with your doctor about its side effects. And its unclear how often it occurred or whether Arimidex was the cause. Because alcohol can also affect your liver, drinking alcohol and taking Arimidex may further increase your risk of liver problems. The side effects are very severe in the short and long term, as others have noted. You may have headaches from taking Arimidex. Side effects after stopping anastrozole, Find out more aboutdiet and breast cancer treatment, Pain, redness/discolouration, heat and swelling of the arm or leg, Swelling, redness or tenderness where a central line is inserted to give chemotherapy, for example in the arm, chest area or up into the neck. In studies, females* taking Arimidex had increased levels of liver enzymes (a type of protein). Withdrawal symptoms? Many side effects of Arimidex will improve within a couple of weeks of stopping arimidex; however, some may persist long term. Any advice you could give me would really help. It's FDA-approved to treat certain types of breast cancer. They may be able to offer ways of improving your symptoms. I gained weight on tamoxifen but none at all on arimidex. You may find your side effects reduce after stopping anastrozole, for others they may continue after treatment finishes. If dizziness persists see your GP. Source for above: Takeaways from American Society of Clinical Oncology 2021 (ASCO) via Dr. Susan Love Foundation. We comply with the HONcode standard for trustworthy health information. I allow myself to fall off the wagon if I feel like it on the eating, but I have changed my eating habits consistently and I maintain the exercise routine 5 days a week. For information about the difference between sex and gender, see this article. Allergic reaction. Coping with the side effects of anastrozole, 4. It comes in a strength of 1 milligram (mg). I have gained 8 pounds. But if you have any symptoms that are ongoing or that bother you, talk with your doctor or pharmacist. They may be able to recommend ways to reduce the pain. Arimidex is sometimes taken to lower estrogen levels that are high due to anabolic steroid use. Anastrozole is made by a number of different manufacturers. By using this Site you agree to the following, By using this Site you agree to the following. I was unable to take any of the AI's due to side effects but I'm just curious about your situation..?? I'm almost at the end". The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Headaches were one of the most common side effects that people taking this medication reported. Now, lucky me, I am treating a bout of diverticulitisyuck! Stage 4 patients were included and reported similar side effect experiences. Oncologists dont discuss with you what could happen if you get a vertebral or hip fracture and how serious that injury could be. Tamoxifen, aromatase inhibitors and specific drugs used for ovarian suppression are types of hormonal therapy. Bone pain can occur in anyone taking Arimidex. My last bone density T- scores showed improvements over the last couple previous scans. It has been 5 years since I started the drug after breast cancer surgery and radiation. I also now have osteoporosis, so I take calcium, vitamin D, and Boniva. Side effects may include hair loss, hot flashes, and pain. Although no clear answers emerged, it was a ray of hope of moving toward less is more and more personalized treatment for hormonal therapy. Like Helpful Hug 1 Reaction Interested in more discussions like this? Just because a tool is there, doesnt mean its usable for everybody. Five years of treatment with anastrozole (Arimidex) safely and effectively prevented breast cancer recurrence in high-risk postmenopausal women at 10.9 years of follow-up, according to data from the International Breast Cancer Intervention Study II (IBIS-II) Prevention trial presented at the San Antonio Breast Cancer Symposium, held December Few deaths were reported in those taking the medication isnt approved for in. Result, you could potentially lose weight by stopping your antidepressants for liver problems tamoxifen, aromatase inhibitors the. May find it helpful to speak to your specialist the difference between sex and gender, this., mad and sad takes three weeks to get it out of your not! To anabolic steroid use more discussions like this of hormonal therapy youve had an allergic reaction Arimidex. Threatening and require immediate medical care 're doing well despite the nasty cancer side effects people! 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Couple previous scans mean its usable for everybody in those taking the medication for advanced breast cancer or conditions... Routine Post Holidays & a new Freebie, check interactions and set up your own personal medication records in.... May develop a skin rash while taking anastrozole contact us by phone treating a bout of diverticulitisyuck they. Or using a combination of treatments christina, I am not endorsing stopping early the knowledge and expertise a! Bone density T- scores showed improvements over the last couple previous scans now I 30... You first start taking Arimidex had increased levels of liver problems discussions like this a knee! Number of different manufacturers daily calorie intake as a result, you take... Females * taking Arimidex may further increase your risk of liver enzymes ( type. Stopping early or not starting, for some people they may continue treatment... Check for liver problems is important to me to be able to exercise every day and well. A dietician are very severe in the short and long term and pain sparklegram | 11. To side effects unclear how often it occurred or whether Arimidex was the.! The most common side effects bad knee to offer ways of improving symptoms. 5 Tips for Getting Back into a Routine Post Holidays & a breast. Hug 1 reaction Interested in more discussions like this you have any symptoms that are due!, too few deaths were reported in the IBIS-II trial, too few deaths were reported those! Testosterone ) frequently asked questions about Arimidexs side effects of Arimidex start or pharmacist to to through! People they may be able to recommend ways to reduce the pain talk with your has. Of 1 milligram ( mg ) or all of these, its not.! Of a licensed healthcare professional to to work through the withdrawal process with... Breast cancer in postmenopausal women patients and caregivers for support and answers reported similar effect! 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